Drug store Technician// Pharmaceutics-I// Aerosols

Aerosols
Aerosols are pressurized dose types including
several than one active components which
upon actuation release a great dispersion of strong and
liquid in gaseous type.
The liquid or strong drug particles are liquified or
suspended in gas. The gas utilized for this function is
referred to as propellant.
Components of Aerosols are:
1. Propellant 2. Container
3. Valve assembly and actuator
4. Item concentrate
1. Propellants
These are chemical compounds which are accountable for establishing pressure
within a container and expel the item when valve is open.
Commonly utilized propellants
Butane, isobutane, Chlorofluorocarbons( difluoroethane, dichlorotetrafluoroethane)
2. Containers
Containers are readily available in tin plate, aluminum, stainless-steel and glass product.
3. Valve Assembly
Function of valve assembly is to allow the expulsion of contents of containers:
In wanted kind
In correct quantity or dosage
It has following parts
1. Installing cup
Used to connect the valve correctly to the
container, made from tin. Aluminum can likewise be
utilized.
2. Real Estate
It consists of an opening at the point of
accessory of dip tube. It is made from nylon.
3. Stem
It supports actuator and provides the item
in appropriate type. Made from nylon, brass and
steel.
4. Gas kat
It is utilized to avoid leak of solution
from container. Made from rubber.
5. Spring
Used to hold gas kat in plate. When actuator
is depressed and launched it returns the valve
to its close position once again.
6. Dip tube
It is utilized to bring solution from container.
Its size differ from formula to solution.
7. Actuator
Its function is to provide the aerosol item in correct and preferred kind.
Spray actuator (Dispersing item into fairly little particles)
Foam actuator (Large orifice)
Solid actuator (Relatively big orifice utilized for semi-solid items)
Specially created actuator (For proper website as nasal, throat, eye)
Metered Valve
These are valves which permit particular quantity of item to come out and after that stop
immediately. Such valves consist of tank of particular volume which on actuation
clears all the contents present in it on single push of actuator.
e.g. metered dosage inhaler (MDI)
4. Item Concentrate
It include: Active active ingredient, Solvent system, Preservative/ Anti-oxidant,
surfactants.

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